Publications resulting from the current Conte Center grant entitled Identification of Cell Type-Specific Actions of Antipsychotic Drugs


  • Alexander, B., Warner-Schmidt, J., Eriksson, T., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., Svenningsson, P., Greengard, P. & Kaplitt, M.G. (2010) Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens. Science Translational Medicine 2(54):54ra76. PMCID: PMC3026098
  • Berger, A.K., Green, T., Siegel, S.J., Nestler, E.J., and Hammer, R.P. (2010) CREB phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D2-like receptor agonist treatment in rats. Biol. Psychiatry 69:288-294. PMCID: PMC3058691
  • Dougherty JD, Schmidt EF, Nakajima M, Heintz N. (2010) Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38(13):4218-30. PMCID: PMC2910036
  • Hara, M., Fukui, R., Hieda, E., Kuroiwa, M., Bateup, H.S., Kano, T., Greengard, P. & Nishi, A. (2010) Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. J Neurochemistry 113(4):1046-1059. PMCID: PMC2861145
  • Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ (2010) Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. PMCID: PMC3011229
  • Ragusa, M.J., Dancheck, B., Critton, D.A., Nairn, A.C., Page, R. and Peti, W. (2010) Spinophilin directs Protein Phosphatase 1 specificity by blocking substrate binding sites. Nature: Structural & Molecular Biology. 17:459-64. PMCID: PMC2924587
  • Ragusa, M.J., Nairn, A.C. and Peti, W. (2010) Flexibility in the PP1:spinophilin holoenzyme. Febs Lett. 585:36-40. PMCID: PMC3017638 [Available on 2012/1/1]
  • Schaefer, A., Im, H-I., Veno, M.T., Fowler, C.D., Min, A., Intrator, A., Kjems, J., Kenny, P.J., O'Carroll, D. & Greengard, P. (2010) Argonaute 2 in dopamine 2 receptor expressing neurons regulates cocaine addiction. Journal of Experimental Medicine 207(9):1843-51. PMCID: PMC2931161
  • Sun, H.S., Green, T.A., Theobald, D.E.H., Laali, S., Shrikhande, G., Birnbaum, S., Kumar, A., Chakravarty, S., Graham, D., Nestler, E.J., and Winstanley, C.A. (2010) The pharmacological stressor yohimbine increases impulsivity through activation of CREB in the orbitofrontal cortex. Biol. Psychiatry 67:649-656. PMCID: PMC2891518
  • Warner-Schmidt, J.L., Chen, E.Y., Zhang, X., Marshall, J.J., Morozov, A., Svenningsson, P. & Greengard, P. (2010) A role for p11 in the antidepressant action of BDNF. Biological Psychiatry 68(6):528-35. PMCID: PMC2929288


  • Ahn, J-H, Kim, Y., Greengard, P. & Nairn, A.C. (2011) Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56delta heterotrimeric form of protein phosphatase 2A. PLos ONE 6(10):e26292. PMCID:PMC3198769
  • Dancheck B, Ragusa MJ, Allaire M, Nairn AC, Page R, Peti W. (2011) Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex. Biochemistry. 50:1238-46. PMCID: PMC3040262 [Available on 2012/2/22]
  • Dietz, D.M., LaPlant, Q., Watts, E.L., Hodes, G.E., Russo, S.J., Feng, J., Oosting, R.S., and Nestler, E.J. (2011) Paternal transmission of stress-induced pathologies. Biol. Psychiatry 70:408-414. PMCID: PMC3217197
  • Gerfen CR, Surmeier DJ (2011) Modulation of striatal projection systems by dopamine. Annu Rev Neurosci 34:441-466. PMID: 21469956 [PubMed - indexed for MEDLINE]
  • Ohnishi, Y.N., Ohnishi, Y.H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Sakumi, K., Nestler, E.J., and Nakabeppu, Y. (2011) FosB Is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ?FosB. Biol. Psychiatry 70:487-495. NIHMSID: 350119
  • Peterson JD, Goldberg JA, Surmeier DJ (2012) Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion. Neurobiol Dis 45:409-416. PMID: 21964253 [PubMed - in process]
  • Plotkin JL, Day M, Surmeier DJ (2011) Synaptically driven state transitions in distal dendrites of striatal spiny neurons. Nat Neurosci 14:881-888. PMID: 21666674 [PubMed - indexed for MEDLINE]
  • Surmeier DJ, Carrillo-Reid L, Bargas J (2011) Dopaminergic modulation of striatal neurons, circuits, and assemblies. Neuroscience 198:3-18. PMID: 21906660 [PubMed - in process]
  • Vialou, V., Cui, H., Perello, M., Mahgoub, M., Yu, H.G., Rush, A.J., Pranav, H., Jung, S., Yanagisawa, M., Zigman, J.M., Elmquist, J.K., Nestler, E.J., and Lutter, M. (2011) A role for ?FosB in calorie restriction-induced metabolic changes. Biol. Psychiatry 70:204-207. PMCID: PMC3125466
  • Warner-Schmidt, J., Vanover, K.E., Chen, E.Y., Marshall, J.J. and Greengard P. (2011) Antidepressant effects of SSRIs are attenuated by anti-inflammatory drugs in mice and humans. Proc. Natl. Acad. Sci. U.S.A. 108(22):9262-9267. PMCID:PMC3107316


  • Davis, M.M., Olausson, P., Greengard, P., Taylor, J.R. & Nairn, A. (2012) Regulator of Calmodulin Signaling (RCS) knockout mice display anxiety-like behavior and motivational deficits. European Journal of Neuroscience. 35(2):300-8 PMID: 22250817 [PubMed - indexed for MEDLINE]
  • Goldberg JA, Ding JB, Surmeier DJ (2012) Muscarinic modulation of striatal function and circuitry. Handbook of experimental pharmacology 208:223-241. PMID: 22222701 [PubMed - indexed for MEDLINE]
  • Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A. (2012) Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex. Psychopharmacology (Berl). 2012 Feb;219(4):1065-79. Epub 2011 Aug 11. PMCID:PMC3539205
  • Chan, C.S., Peterson, J.D., Gertler, T.S., Glajch, K.E., Quintana, R.E., Cui, Q., Sebel, L.E., Plotkin, J.L., Shen, W., Heiman, M., Heintz, N., Greengard, P., Surmeier, D.J. (2012) Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice. J. Neurosci 32, 9124-9132.  PMCID: PMC3461272
  • Eriksson, T.M., Alvarsson, A., Stan, T.L., Zhang, X., Hascup, K.N., Hascup, E.R., Kehr, J., Gerhard, G.A., Warner-Schmidt, J., Arango-Lievano, M., Kaplitt, M.G., Ogren, S.O., Greengard, P. & Svenningsson, P. (2012) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry doi: 10.1038/mp.2012.130 (Epub ahead of print). PMID:23032875 [PubMed - as supplied by publisher]
  • Kurita, M., Holloway, T., Garcia-Bea, A., Kozlenkov, A., Friedman, A.K., Moreno, J.L., Heshmati, M., Golden, S.A., Kennedy, P.J., Takahashi, N., Dietz, D.M., Mocci, G., Gabilondo, A.M., Hanks, J., Umali, A., Callado, L.F., Gallitano, A.L., Neve, R.L., Shen, L., Buxbaum, J.D., Han, M.H., Nestler, E.J., Meana, J.J., Russo, S.J., and Gonzalez-Maeso, J. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGluR2 promoter activity. Nature Neurosci. 15:1245-1254. PMCID: PMC3431440
  • Mellen, M., Ayata, P., Dewell, S., Kriaucionis, S, Heintz, N. (2012). MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system.  Cell 151(7):1-14. PMID: 23260135 [PubMed - indexed for MEDLINE]
  • Santini, E., Feyder, M., Gangarossa, G., Bateup, H.S., Greengard, P. & Fisone, G. (2012) Dopamine- and cAMP-regulated phosphoprotein of 32kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin complex 1 (mTORC1) signaling in experimental Parkinsonism. Journal of Biological Chemistry 287(33):27806-12. PMCID: PMC3431653
  • Schmidt, E.F., Warner-Schmidt, J.L., Otopalik, B.G., Pickett, D.B. Greengard, P. and N. Heintz.  (2012) Identification of the cortical neurons that mediate antidepressant responses.  Cell 149(5):1152-63 PMCID: PMC3397430
  • Tronson, N.C., Wiseman, S.L., Neve, R.L., Nestler, E.J., Olausson, P., and Taylor, J.R. (2012) Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory. Learning Memory 19178-181. PMCID:PMC3348518
  • Warner-Schmidt J.L., Schmidt, E.F., Marshall, J.J., Rubin, A.J., Arango-Lievano, M., Kaplitt, M.G., Ibañez-Tallon, I., Heintz, N. and P. Greengard.  (2012) Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proc Natl Acad Sci U S A. 109:11360-11365.  PMCID: PMC3396525

Book Chapters

  • Sweatt, J.D., Nestler, E.J., Meaney, M.J., and Akbarian, S. (Eds.) (2012) Epigenetic Regulation in the Nervous System. Academic Press, New York.


  • Borroto-Escuela, D.O., Flajolet, M., Agnati, L.F., Greengard, P. & Fuxe, K. (2013) Bioluminescence Resonance Energy Transfer Methods to Study G Protein-Coupled Receptor-Receptor Tyrosine Kinase Heteroreceptor Complexes. Methods Cell Biol. 2013;117:141-64. PMCID: PMC3921556
  • Craft, G.E., Chen, A., and Nairn. A.C. (2013) Recent advances in quantitative neuroproteomics. Methods. 61:186-218. PMCID: PMC3891841 Available on 2014/6/15
  • Fishell, G. and N. Heintz (2013) The neuron identity problem: form meets function. Neuron 80:602-612. PMID: 24360541 [PubMed - in process]
  • Greengard, P., Nestler, E.J. (2013) A conversation with Paul Greengard. Annu Rev Pharmacol Toxicol 53:1-16. PMID: PMC23294305
  • Jordi, E., Heiman, M., Marion-Poll, L., Guermonprez, P., Cheng, S.-K., Nairn A., Greengard, P. and Girault, J.-A. (2013) Differential effects of cocaine on histone post-translational modifications in the two populations of striatal medium-sized spiny neurons. Proc. Natl. Acad. Sci. USA 110:9511-6. doi: 10.1073/pnas.1307116110. PMID: PMC3677456
  • Kurita, M., Moreno, J.L., Holloway, T., Kozlenkov, A., Mocci, G., Garcia-Bea, A., Hanks, J.B., Neve, R., Nestler, E.J., Russo, S.J., and Gonzalez-Maeso, J. (2013) Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol. Pharmacol. 83:1166-1175. PMCID: PMC3657099
  • Lobo, M.K., Zaman, S., Damez-Werno, D.M., Koo, J.W., Bagot, R.C., DiNieri, J.A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., Ribeiro, E., Rabkin, J., Mouzon, E., Cachope, R., Cheer, J.F., Han, M.H., Dietz, D.M., Self, D.W., Hurd, Y.L., Vialou, V., and Nestler, E.J. (2013) ∆FosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J. Neurosci. 33:18381-18395. PMCID: PMC3834048
  • Oh, Y-S., Gao, P., Lee, K., Ceglia, I., Zhang, X., Ahn, J-H.,Chait, B.T., Kim, Y., Patel, D.J. & Greengard, P. (2013) SMARCA3, a chromatic remodeling factor, is required for p11-dependent antidepressant action. Cell 152:831-43. PMID: PMC3633087
  • Svenningsson, P., Kim, Y., Warner-Schmidt, J., Oh, Y-S. & Greengard P. (2013) Role of p11 (S100A10) in depression and in therapeutic responses to antidepressants. Nature Reviews Neuroscience 14:673-680. PMCID in process NIHMS553175
  • Tan, C.L., Plotkin, J.L. Veno, M.T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D.J., O’Carroll, D., Greengard, P. & Schaefer, A. (2013) MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 342:1254-1258. PMCID in process NIHMS554436


  • Dietz, D.M., Kennedy, P.J., Sun, H.S., Maze, I., Gancarz, A.M., Vialou, V., Koo, J.W., Mouzon, E., Ghose, S., Tamminga, C.A., and Nestler, E.J. (2014) ∆FosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes. Neuropsychopharmacology, 39:538-44. PMCID: PMC3895248

Publications resulting from the previous Conte Center grant entitled Signaling Mechanisms Underlying Neuroleptic Drug Actions






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