Publications

Publications resulting from the current Conte Center grant entitled Identification of Cell Type-Specific Actions of Antipsychotic Drugs

2010

Alexander, B., Warner-Schmidt, J., Eriksson, T., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., Svenningsson, P., Greengard, P. & Kaplitt, M.G. (2010) Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens. Science Translational Medicine 2(54):54ra76. PMCID: PMC3026098
Berger, A.K., Green, T., Siegel, S.J., Nestler, E.J., and Hammer, R.P. (2010) CREB phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D2-like receptor agonist treatment in rats. Biol. Psychiatry 69:288-294. PMCID: PMC3058691
Dougherty JD, Schmidt EF, Nakajima M, Heintz N. (2010) Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells. Nucleic Acids Res. 38(13):4218-30. PMCID: PMC2910036
Hara, M., Fukui, R., Hieda, E., Kuroiwa, M., Bateup, H.S., Kano, T., Greengard, P. & Nishi, A. (2010) Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. J Neurochemistry 113(4):1046-1059. PMCID: PMC2861145
Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ (2010) Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385-390. PMCID: PMC3011229
Ragusa, M.J., Dancheck, B., Critton, D.A., Nairn, A.C., Page, R. and Peti, W. (2010) Spinophilin directs Protein Phosphatase 1 specificity by blocking substrate binding sites. Nature: Structural & Molecular Biology. 17:459-64. PMCID: PMC2924587
Ragusa, M.J., Nairn, A.C. and Peti, W. (2010) Flexibility in the PP1:spinophilin holoenzyme. Febs Lett. 585:36-40. PMCID: PMC3017638 [Available on 2012/1/1]
Schaefer, A., Im, H-I., Veno, M.T., Fowler, C.D., Min, A., Intrator, A., Kjems, J., Kenny, P.J., O'Carroll, D. & Greengard, P. (2010) Argonaute 2 in dopamine 2 receptor expressing neurons regulates cocaine addiction. Journal of Experimental Medicine 207(9):1843-51. PMCID: PMC2931161
Sun, H.S., Green, T.A., Theobald, D.E.H., Laali, S., Shrikhande, G., Birnbaum, S., Kumar, A., Chakravarty, S., Graham, D., Nestler, E.J., and Winstanley, C.A. (2010) The pharmacological stressor yohimbine increases impulsivity through activation of CREB in the orbitofrontal cortex. Biol. Psychiatry 67:649-656. PMCID: PMC2891518
Warner-Schmidt, J.L., Chen, E.Y., Zhang, X., Marshall, J.J., Morozov, A., Svenningsson, P. & Greengard, P. (2010) A role for p11 in the antidepressant action of BDNF. Biological Psychiatry 68(6):528-35. PMCID: PMC2929288

2011

Ahn, J-H, Kim, Y., Greengard, P. & Nairn, A.C. (2011) Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56delta heterotrimeric form of protein phosphatase 2A. PLos ONE 6(10):e26292. PMCID:PMC3198769
Dancheck B, Ragusa MJ, Allaire M, Nairn AC, Page R, Peti W. (2011) Molecular investigations of the structure and function of the protein phosphatase 1-spinophilin-inhibitor 2 heterotrimeric complex. Biochemistry. 50:1238-46. PMCID: PMC3040262 [Available on 2012/2/22]
Dietz, D.M., LaPlant, Q., Watts, E.L., Hodes, G.E., Russo, S.J., Feng, J., Oosting, R.S., and Nestler, E.J. (2011) Paternal transmission of stress-induced pathologies. Biol. Psychiatry 70:408-414. PMCID: PMC3217197
Gerfen CR, Surmeier DJ (2011) Modulation of striatal projection systems by dopamine. Annu Rev Neurosci 34:441-466. PMID: 21469956 [PubMed - indexed for MEDLINE]
Ohnishi, Y.N., Ohnishi, Y.H., Hokama, M., Nomaru, H., Yamazaki, K., Tominaga, Y., Sakumi, K., Nestler, E.J., and Nakabeppu, Y. (2011) FosB Is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ?FosB. Biol. Psychiatry 70:487-495. NIHMSID: 350119
Peterson JD, Goldberg JA, Surmeier DJ (2012) Adenosine A2a receptor antagonists attenuate striatal adaptations following dopamine depletion. Neurobiol Dis 45:409-416. PMID: 21964253 [PubMed - in process]
Plotkin JL, Day M, Surmeier DJ (2011) Synaptically driven state transitions in distal dendrites of striatal spiny neurons. Nat Neurosci 14:881-888. PMID: 21666674 [PubMed - indexed for MEDLINE]
Surmeier DJ, Carrillo-Reid L, Bargas J (2011) Dopaminergic modulation of striatal neurons, circuits, and assemblies. Neuroscience 198:3-18. PMID: 21906660 [PubMed - in process]
Vialou, V., Cui, H., Perello, M., Mahgoub, M., Yu, H.G., Rush, A.J., Pranav, H., Jung, S., Yanagisawa, M., Zigman, J.M., Elmquist, J.K., Nestler, E.J., and Lutter, M. (2011) A role for ?FosB in calorie restriction-induced metabolic changes. Biol. Psychiatry 70:204-207. PMCID: PMC3125466
Warner-Schmidt, J., Vanover, K.E., Chen, E.Y., Marshall, J.J. and Greengard P. (2011) Antidepressant effects of SSRIs are attenuated by anti-inflammatory drugs in mice and humans. Proc. Natl. Acad. Sci. U.S.A. 108(22):9262-9267. PMCID:PMC3107316

2012

Davis, M.M., Olausson, P., Greengard, P., Taylor, J.R. & Nairn, A. (2012) Regulator of Calmodulin Signaling (RCS) knockout mice display anxiety-like behavior and motivational deficits. European Journal of Neuroscience. 35(2):300-8 PMID: 22250817 [PubMed - indexed for MEDLINE]
Goldberg JA, Ding JB, Surmeier DJ (2012) Muscarinic modulation of striatal function and circuitry. Handbook of experimental pharmacology 208:223-241. PMID: 22222701 [PubMed - indexed for MEDLINE]
Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A. (2012) Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex. Psychopharmacology (Berl). 2012 Feb;219(4):1065-79. Epub 2011 Aug 11. PMCID:PMC3539205
Chan, C.S., Peterson, J.D., Gertler, T.S., Glajch, K.E., Quintana, R.E., Cui, Q., Sebel, L.E., Plotkin, J.L., Shen, W., Heiman, M., Heintz, N., Greengard, P., Surmeier, D.J. (2012) Strain-Specific Regulation of Striatal Phenotype in Drd2-eGFP BAC Transgenic Mice. J. Neurosci 32, 9124-9132. PMCID: PMC3461272
Eriksson, T.M., Alvarsson, A., Stan, T.L., Zhang, X., Hascup, K.N., Hascup, E.R., Kehr, J., Gerhard, G.A., Warner-Schmidt, J., Arango-Lievano, M., Kaplitt, M.G., Ogren, S.O., Greengard, P. & Svenningsson, P. (2012) Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11. Mol Psychiatry doi: 10.1038/mp.2012.130 (Epub ahead of print). PMID:23032875 [PubMed - as supplied by publisher]
Kurita, M., Holloway, T., Garcia-Bea, A., Kozlenkov, A., Friedman, A.K., Moreno, J.L., Heshmati, M., Golden, S.A., Kennedy, P.J., Takahashi, N., Dietz, D.M., Mocci, G., Gabilondo, A.M., Hanks, J., Umali, A., Callado, L.F., Gallitano, A.L., Neve, R.L., Shen, L., Buxbaum, J.D., Han, M.H., Nestler, E.J., Meana, J.J., Russo, S.J., and Gonzalez-Maeso, J. (2012) HDAC2 regulates atypical antipsychotic responses through the modulation of mGluR2 promoter activity. Nature Neurosci. 15:1245-1254. PMCID: PMC3431440
Mellen, M., Ayata, P., Dewell, S., Kriaucionis, S, Heintz, N. (2012). MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 151(7):1-14. PMID: 23260135 [PubMed - indexed for MEDLINE]
Santini, E., Feyder, M., Gangarossa, G., Bateup, H.S., Greengard, P. & Fisone, G. (2012) Dopamine- and cAMP-regulated phosphoprotein of 32kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin complex 1 (mTORC1) signaling in experimental Parkinsonism. Journal of Biological Chemistry 287(33):27806-12. PMCID: PMC3431653
Schmidt, E.F., Warner-Schmidt, J.L., Otopalik, B.G., Pickett, D.B. Greengard, P. and N. Heintz. (2012) Identification of the cortical neurons that mediate antidepressant responses. Cell 149(5):1152-63 PMCID: PMC3397430
Tronson, N.C., Wiseman, S.L., Neve, R.L., Nestler, E.J., Olausson, P., and Taylor, J.R. (2012) Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory. Learning Memory 19178-181. PMCID:PMC3348518
Warner-Schmidt J.L., Schmidt, E.F., Marshall, J.J., Rubin, A.J., Arango-Lievano, M., Kaplitt, M.G., Ibañez-Tallon, I., Heintz, N. and P. Greengard. (2012) Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proc Natl Acad Sci U S A. 109:11360-11365. PMCID: PMC3396525

Book Chapters

Sweatt, J.D., Nestler, E.J., Meaney, M.J., and Akbarian, S. (Eds.) (2012) Epigenetic Regulation in the Nervous System. Academic Press, New York.

2013

Borroto-Escuela, D.O., Flajolet, M., Agnati, L.F., Greengard, P. & Fuxe, K. (2013) Bioluminescence Resonance Energy Transfer Methods to Study G Protein-Coupled Receptor-Receptor Tyrosine Kinase Heteroreceptor Complexes. Methods Cell Biol. 2013;117:141-64. PMCID: PMC3921556
Craft, G.E., Chen, A., and Nairn. A.C. (2013) Recent advances in quantitative neuroproteomics. Methods. 61:186-218. PMCID: PMC3891841 Available on 2014/6/15
Fishell, G. and N. Heintz (2013) The neuron identity problem: form meets function. Neuron 80:602-612. PMID: 24360541 [PubMed - in process]
Greengard, P., Nestler, E.J. (2013) A conversation with Paul Greengard. Annu Rev Pharmacol Toxicol 53:1-16. PMID: PMC23294305
http://www.ncbi.nlm.nih.gov/pubmed/23294305
Jordi, E., Heiman, M., Marion-Poll, L., Guermonprez, P., Cheng, S.-K., Nairn A., Greengard, P. and Girault, J.-A. (2013) Differential effects of cocaine on histone post-translational modifications in the two populations of striatal medium-sized spiny neurons. Proc. Natl. Acad. Sci. USA 110:9511-6. doi: 10.1073/pnas.1307116110. PMID: PMC3677456
Kurita, M., Moreno, J.L., Holloway, T., Kozlenkov, A., Mocci, G., Garcia-Bea, A., Hanks, J.B., Neve, R., Nestler, E.J., Russo, S.J., and Gonzalez-Maeso, J. (2013) Repressive epigenetic changes at the mGlu2 promoter in frontal cortex of 5-HT2A knockout mice. Mol. Pharmacol. 83:1166-1175. PMCID: PMC3657099
Lobo, M.K., Zaman, S., Damez-Werno, D.M., Koo, J.W., Bagot, R.C., DiNieri, J.A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., Ribeiro, E., Rabkin, J., Mouzon, E., Cachope, R., Cheer, J.F., Han, M.H., Dietz, D.M., Self, D.W., Hurd, Y.L., Vialou, V., and Nestler, E.J. (2013) ∆FosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J. Neurosci. 33:18381-18395. PMCID: PMC3834048
Oh, Y-S., Gao, P., Lee, K., Ceglia, I., Zhang, X., Ahn, J-H.,Chait, B.T., Kim, Y., Patel, D.J. & Greengard, P. (2013) SMARCA3, a chromatic remodeling factor, is required for p11-dependent antidepressant action. Cell 152:831-43. PMID: PMC3633087
http://www.sciencedirect.com/science/article/pii/S0092867413000202
Svenningsson, P., Kim, Y., Warner-Schmidt, J., Oh, Y-S. & Greengard P. (2013) Role of p11 (S100A10) in depression and in therapeutic responses to antidepressants. Nature Reviews Neuroscience 14:673-680. PMCID in process NIHMS553175
Tan, C.L., Plotkin, J.L. Veno, M.T., von Schimmelmann, M., Feinberg, P., Mann, S., Handler, A., Kjems, J., Surmeier, D.J., O’Carroll, D., Greengard, P. & Schaefer, A. (2013) MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 342:1254-1258. PMCID in process NIHMS554436

2014

Dietz, D.M., Kennedy, P.J., Sun, H.S., Maze, I., Gancarz, A.M., Vialou, V., Koo, J.W., Mouzon, E., Ghose, S., Tamminga, C.A., and Nestler, E.J. (2014) ∆FosB induction in prefrontal cortex by antipsychotic drugs is associated with negative behavioral outcomes. Neuropsychopharmacology, 39:538-44. PMCID: PMC3895248

Publications resulting from the previous Conte Center grant entitled Signaling Mechanisms Underlying Neuroleptic Drug Actions

2005

Jin, M., Bateup, H., Padovan, J.C., Greengard, P., Nairn, A.C., Chait, B.T. Quantitative analysis of protein phosphorylation in mouse brain by hypothesis-driven multistage mass spectrometry. Anal. Chem. 2005 Dec 15;77(24):7845-51.
Uematsu, K. Futter, M. Hsieh-Wilson, L.C., Higashi, H., Maeda, H., Nairn, A.C., Greengard P., and Nishi, A. (2005) Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways. J Neurochem. 95:1642-52.

2006

Allen PB, Zachariou V, Svenningsson P, Lepore AC, Centonze D, Costa C, Rossi S, Bender G, Chen G, Feng J, Snyder GL, Bernardi G, Nestler EJ, Yan Z, Calabresi P, Greengard P. (2006) Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neuroscience. Jul 7;140(3):897-911.
Ding J, Guzman JN, Tkatch T, Chen S, Goldberg JA, Ebert PJ, Levitt P, Wilson CJ, Hamm HE, Surmeier DJ (2006) RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci 9:832-842.
Hakansson, K., Galdi, S., Hendrick, J., Snyder, G., Greengard, P., Fisone, G. Regulation of phosphorylation of the GluR1 AMPA receptor by dopamine D2 receptors. J Neurochem. 2006 Jan;96(2):482-8.
Krueger, D.D., Howell, J., Fabacher, B., Olausson, P., Taylor, J.R., Nairn, A.C. (2006) Assessment of cognitive function in the heterozygous reeler mouse. Psychopharmacology. 189:95-104.
Rogers, J.P., Beuscher, A.E. 4th, Flajolet, M., McAvoy, T., Nairn, A.C., Olson, A.J., Greengard, P. Discovery of protein phosphatase 2C inhibitors by virtual screening. J. Med. Chem. 2006 Mar 9;49(5):1658-67.
Scott L, Zelenin S, Malmersjo S, Kowalewski JM, Markus EZ, Nairn AC, Greengard P, Brismar H, Aperia A. (2006) Allosteric changes of the NMDA receptor trap diffusible dopamine 1 receptors in spines. Proc Natl Acad Sci U S A. Jan 17;103(3):762-7.
Yabuuchi K, Kuroiwa M, Shuto T, Sotogaku N, Snyder GL, Higashi H, Tanaka M, Greengard P, Nishi A. (2006) Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum. Neuroscience. Aug 11;141(1):19-25.
Zachariou V, Sgambato-Faure V, Sasaki T, Svenningsson P, Fienberg AA, Nairn AC, Greengard P, Nestler EJ (2006) Phosphorylation of DARPP-32 at threonine-34 is required for cocaine action. Neuropsychopharmacology 31:555-562.

2007

Ahn, J-H., Sung, J.Y., McAvoy, T., Nishi, A., Janssens, V., Goris, J., Greengard, P., Nairn, A.C. (2007) The B"/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by Protein Phosphatase 2A. Proc. Natl. Acad. Sci. 104(223):9876-9881.
Barbano, P., Spivak, M, Flajolet, M., Nairn, A., Greengard, P., Greengard L. (2007) A mathematical tool for exploring the dynamics of biology networks. Proc. Natl. Acad. Sci. 104(49):19169-19174.
Carle, T.L., Ohnishi. Y.N., Ohnishi, Y.H., Alibhai, I.N., Wilkinson, M.B., Kumar, A., and Nestler, E.J. (2007) Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for FosB stability. Eur. J. Neurosci. 25:3009-3019.
Carr, D.B., Surmeier, D.J. (2007) M1 muscarinic receptor modulation of Kir2 channels enhances temporal summation of excitatory synaptic potentials in prefrontal cortex pyramidal neurons. J. Neurophysiol. 97(5):3432-8.
Hawasli, A.H., Benavides, D.R., Nguyen, C., Kansy, J.W., Chambon, P., Greengard, P., Powell, C.M., Cooper, D.C., Bibb, J.A. (2007) Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nature Neuroscience. 10(7):880-886.
Jorissen, H., Ulery, P., Henry, L., Gourneni, S., Nestler, E.J., and Rudenko, G. (2007) Dimerization and DNA-binding properties of the transcription factor deltaFosB. Biochemistry 46:8360-8372.
Ju, T., Ragusa, M.J., Hudak, J., Nairn, A.C., Peti, W. (2007) Structural characterization of the neurabin SAM domain. Proteins 69:192-198.
Kelker, M.S., Dancheck, B., Ju, T., Kessler, R., Hudak, J., Nairn, A.C., and Peti, W. (2007) Structural Basis for Spinophilin and Neurabin Receptor Interaction. Biochemistry 46:2333-2344.
Kimura, T., Allen, P.B., Nairn, A.C., Caplan, M.J. (2007) Arrestins and spinophilin competitively regulate Na+,K+-ATPase trafficking through association with a large cytoplasmic loop of the Na+,K+-ATPase. Mol. Biol. Cell 18:4508-4518.
Shen, W., Tian, X., Day, M., Ulrich, S., Tkatch, T., Nathanson, NM., Surmeier, D.J. (2007) Cholinergic modulation of Kir2 channels selectively elevates dendritic excitability in striatopallidal neurons. Nat Neurosci. 10(11):1458-66.
Winstanley, C.A., LaPlant, Q., Theobald, D.E.H., Green, T.A., Bachtell, R.K., Perrotti, L.I., DiLeone, F.J., Russo, S.J., Garth, W.J., Self, D.W., and Nestler, E.J. (2007) FosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J. Neurosci. 27:10497-10507.
Xie Z, Srivastava DP, Photowala H, Kai L, Cahill ME, Woolfrey KM, Shum CY, Surmeier DJ, Penzes P (2007) Kalirin-7 controls activity-dependent structural and functional plasticity of dendritic spines. Neuron 56:640-656.
Zhang, X., Andren, P.E., Greengard, P., Svenningsson, P. (2007) Evidence for a role of the 5-HT1b receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism. Proc. Natl. Acad. Sci. 105:2163-2168.

2008

Bateup, H.S., Svenningsson, P., Kuroiwa, M., Gong, S., Nishi, A., Heintz, N., & Greengard, P. (2008) Cell-type specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nature Neuroscience. 11(8):932-939.
Borrelli, E., Nestler, E.J., Allis, C.D., and Sassone-Corsi, P. (2008) Decoding the epigenetic language of neuronal plasticity. Neuron 60:961-974.
Dancheck,B., Nairn,A.C., and Peti,W. (2008). Detailed structural characterization of unbound protein phosphatase 1 inhibitors. Biochemistry 47, 12346-12356.
Day, M., Wokosin, D., Plotkin, J.L., Tian, X. & Surmeier, D.J. (2008) Differential excitability and modulation of striatal medium spiny neuron dendrites. J. Neurosci. 28(45):11603-11614.
Doyle, J.P., Dougherty, J.D., Heiman, M., Schmidt, E.F., Stevens, T.R., Ma, G., Bupp, S., Shrestha, P., Shah, R.D., Doughty M.L., Gong, S., Greengard, P., & Heintz, N. (2008) Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types. Cell 135(4):749-762.
Flajolet, M., Wang, Z., Futter, M., Shen, W., Nuangchamnong, N., Bendor, J., Wallach, I., Nairn, A.C., Surmeier, D.J. & Greengard, P. (2008) FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity. Nature Neuroscience 11(12):1402-1409.
Flynn,M.P., Maizels,E.T., Karlsson,A.B., McAvoy,T., Ahn,J.H., Nairn,A.C., and Hunzicker-Dunn,M. (2008). Luteinizing hormone receptor activation in ovarian granulosa cells promotes protein kinase A-dependent dephosphorylation of microtubule-associated protein 2D. Mol. Endocrinol. 22, 1695-1710.
Gertler, T.S., Chan, C.S. & Surmeier, D.J. (2008) Dichotomous anatomical properties of adult striatal medium spiny neurons. J. Neurosci. 28(43):10814 -10824.
Green, T.A., Alibhai, I.N., Unterberg, S., Neve, R.L., Ghose, S., Tamminga, C.A., Nestler, E.J. (2008) Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior. J. Neurosci. 2008 Feb 27;28(9):2025-32.
Heiman, M., Schaefer, A., Gong, S., Peterson, J.D., Day, M., Ramsey, K.E., Saurez-Farinas, M., Schwarz, C., Stephan, D.A., Surmeier, D.J., Greengard, P. & Heintz, N. (2008) A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types. Cell 135(4):738-48.
Lagace, D.C., Benavides, D.R., Kansy, J.W., Mapelli, M., Greengard, P., Bibb, J.A. & Eisch, A.J. (2008) Cdk5 is essential for adult hippocampal neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 105(47):18567-18571.
McClung, C.A. and Nestler, E.J. (2008) Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33:3-17.
Nestler, E.J. and Tecott, L.H. (2008) Rodent behaviour: Approaches. In: Encyclopedia of Neuroscience, ed. by L.R. Squire, Academic Press, Oxford, Ch 887, vol. 8, pp. 407-413.
O'Sullivan, G.J., Dunleavy, M., Hakansson, K., Clementi, M., Kinsella, A., Croke. D.T., Drago, J., Fienberg, A.A., Greengard, P., Sibley, D.R., Fisone, G., Henshall, D.C. & Waddington, J.L. (2008) Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. Neuropharmacology. 54(7): 1051-1061.
Pulipparacharuvil, S., Renthal, W., Hale, C.F., Taniguchi, M., Xiao, G.H., Kumar, A., Russo, S.J., Sikder, D., Dewey, C.M., Davis, M.M., Greengard, P., Nairn, A.C., Nestler, E.J., and Cowan, C.W. (2008) Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron 59:621-633.
Shen, W., Flajolet, M., Greengard, P. & Surmeier, D.J. (2008) Dichotomous dopaminergic control of striatal synaptic plasticity. Science 321, 848-851.
Stipanovich, A., Valjent, E., Matamales, M., Nishi, A., Ahn, J-H., Maroteaux, M., Bertran-Gonzales, J., Brami-Cherrier, K., Enslen, H., Corbille, A-G., Filhol, O., Nairn, A.C., Greengard, P., Herve, D., & Girault, J.A. (2008) A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature 453, 879-884.
Taverna, S., Ilijic, E. & Surmeier, D.J. (2008) Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease. J. Neurosci. 28, 5504-5512.

2009

Bertran-Gonzalez,J., Hakansson,K., Borgkvist,A., Irinopoulou,T., Brami-Cherrier,K., Usiello,A., Greengard,P., Herve,D., Girault,J.A., Valjent,E., and Fisone,G. (2009). Histone H3 Phosphorylation is Under the Opposite Tonic Control of Dopamine D2 and Adenosine A2A Receptors in Striatopallidal Neurons. Neuropsycho-pharmacology.
McAvoy,T., Zhou,M.M., Greengard,P., and Nairn,A.C. (2009). Phosphorylation of Rap1GAP, a striatally enriched protein, by protein kinase A controls Rap1 activity and dendritic spine morphology. Proc. Natl. Acad. Sci. U. S. A 106, 3531-3536.
Ulery-Reynolds, P.G., Castillo, M.A., Vialou, V., Russo, S.J., and Nestler, E.J. (2009) Phosphorylation of ?FosB mediates its stability in vivo. Neuroscience 158:369-372.
Warner-Schmidt,J.L., Flajolet,M., Maller,A., Chen,E.Y., Qi,H., Svenningsson,P., and Greengard,P. (2009). Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J. Neurosci. 29, 1937-1946.

Project Leaders

Paul Greengard, Ph.D.
Laboratory of Molecular and Cellular Neuroscience
The Rockefeller University
New York, NY
Nathaniel Heintz, Ph.D.
Laboratory of Molecular Biology
The Rockefeller University
New York, NY
Angus C. Nairn, Ph.D.
Division of Molecular Psychiatry
Yale University School of Medicine
New Haven, CT
Eric J. Nestler, Ph.D./M.D.
Mount Sinai School of Medicine
New York, NY
D. James Surmeier, Ph.D.
Department of Physiology
Northwestern University
Chicago, IL